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Issue 4, 2010
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Antimicrobial polysiloxane polymers and coatings containing pendant levofloxacin

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Abstract

A broad-spectrum antimicrobial drug, levofloxacin, was successfully incorporated into a siloxane coating by covalent attachment. First, an epoxy-functional poly(dimethylsiloxane) (Ep-PDMS) was synthesized by platinum-catalyzed hydrosilylation using poly(methylhydro-co-dimethyl)siloxane and allyl glycidyl ether. Next, levofloxacin was reacted with Ep-PDMS using a stoichiometric excess of epoxy groups relative to levofloxacin to produce a siloxane copolymer containing both pendant levofloxacin and epoxy moieties (levo-Ep-PDMS). Since attachment (i.e. tethering) of levofloxacin occurred via ring-opening of epoxy groups by the carboxylic acid group of levofloxacin, the tether produced was an ester-functional tether. Crosslinked surface coatings were produced by solution blending the polymer with diethylenetriamine as a crosslinker. Compared to a control coating produced by simply blending levofloxacin into a polysiloxane, the coating containing tethered levofloxacin moieties displayed a uniform distribution of levofloxacin, higher initial kill, and sustained antimicrobial surface activity.

Graphical abstract: Antimicrobial polysiloxane polymers and coatings containing pendant levofloxacin

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Publication details

The article was received on 20 Oct 2009, accepted on 28 Dec 2009 and first published on 28 Jan 2010


Article type: Paper
DOI: 10.1039/B9PY00309F
Citation: Polym. Chem., 2010,1, 442-452

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    Antimicrobial polysiloxane polymers and coatings containing pendant levofloxacin

    A. Kugel, B. Chisholm, S. Ebert, M. Jepperson, L. Jarabek and S. Stafslien, Polym. Chem., 2010, 1, 442
    DOI: 10.1039/B9PY00309F

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