Issue 2, 2010
From the journal:

Polymer Chemistry

Self-exploding capsules

Bruno G. De Geest,*a   Stefaan De Koker,b   Jo Demeester,c   Stefaan C. De Smedtc  and  Wim E. Henninkd  

* Corresponding authors

a Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Ghent, Belgium
E-mail: Br.DeGeest@ugent.be

b Laboratory of Molecular Immunology, Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium

c Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics, Ghent University, Belgium

d Department of Pharmaceutics, Utrecht University, Utrecht, The Netherlands

Abstract

Self-exploding microcapsules are core-shell capsules that consist of a degradable microgel core surrounded by a semi-permeable membrane. When the microgel core degrades, the swelling pressure increases and finally the rupture of the surrounding membrane leads to release of the encapsulated species. This type of capsule could find applications in fields such as e.g. drug delivery, tissue engineering and microfluidics.

Graphical abstract: Self-exploding capsules

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Article information

DOI
https://doi.org/10.1039/B9PY00287A
Article type
Review Article
Submitted
09 Oct 2009
Accepted
02 Nov 2009
First published
24 Dec 2009

Polym. Chem., 2010,1, 137-148

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Self-exploding capsules

B. G. De Geest, S. De Koker, J. Demeester, S. C. De Smedt and W. E. Hennink, Polym. Chem., 2010, 1, 137 DOI: 10.1039/B9PY00287A

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