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Issue 2, 2019
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In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

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Abstract

The facile synthesis and in vitro activity of a library of heavy atom-free BODIPY-anthracene, -pyrene dyads (BAD-13–BPyrD-19) and a control (BODIPY 20) are reported. We demonstrate that singlet oxygen produced from dyad triplet states formed from charge-separated states is sufficient to induce cytotoxicity in human breast cancer cells (MDA-MB-468) at micromolar concentrations. The compounds in this series are promising candidates for photodynamic therapy, especially BAD-17 which displays significant photocytotoxicity (15% cell viability) at a concentration of 5 × 10−7 M, with minimal toxicity (89% cell viability) in the absence of light.

Graphical abstract: In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

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Publication details

The article was received on 13 Sep 2018, accepted on 09 Jan 2019 and first published on 11 Jan 2019


Article type: Paper
DOI: 10.1039/C8PP00402A
Photochem. Photobiol. Sci., 2019,18, 495-504

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    In vitro cytotoxicity of a library of BODIPY-anthracene and -pyrene dyads for application in photodynamic therapy

    S. Callaghan, M. A. Filatov, H. Savoie, R. W. Boyle and M. O. Senge, Photochem. Photobiol. Sci., 2019, 18, 495
    DOI: 10.1039/C8PP00402A

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