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Issue 2, 2019
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Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

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Abstract

Lipid membrane-incorporated porphyrin derivatives (LMIPors) having three phenyl moieties and one pyridyl or pyridinium moiety at the meso-positions were more stable than LMIPors having phenyl and/or pyridyl moieties. The former two LMIPors showed high photodynamic activity toward cancer cells under photoirradiation at wavelengths over 600 nm, which are the most suitable for photodynamic therapy. The photodynamic activities were greater than that of Photofrin, which is currently the main drug employed clinically as a photosensitiser. The results represent significant progress toward the optimisation of LMIPors as photosensitisers.

Graphical abstract: Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

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Supplementary files

Article information


Submitted
30 Jul 2018
Accepted
19 Nov 2018
First published
20 Nov 2018

Photochem. Photobiol. Sci., 2019,18, 459-466
Article type
Paper

Stabilisation of lipid membrane-incorporated porphyrin derivative aqueous solutions and their photodynamic activities

T. Nakaya, B. Horiguchi, S. Hino, K. Sugikawa, H. Funabashi, A. Kuroda and A. Ikeda, Photochem. Photobiol. Sci., 2019, 18, 459 DOI: 10.1039/C8PP00350E

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