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Issue 3, 2012
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Caged glucosamine-6-phosphate for the light-control of riboswitch activity

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Abstract

We have synthesized a light-activatable (“caged”) derivative of glucosamine-6-phosphate (GlcN6P), which only upon irradiation becomes a cofactor for the glmS riboswitch. This glmS riboswitch maintains its activity when embedded in the 3′-untranslated region of eukaryotic mRNA molecules and caged GlcN6P reduces the amount of translated EGFP upon irradiation with light in vitro.

Graphical abstract: Caged glucosamine-6-phosphate for the light-control of riboswitch activity

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Article information


Submitted
05 Aug 2011
Accepted
22 Sep 2011
First published
17 Oct 2011

Photochem. Photobiol. Sci., 2012,11, 489-492
Article type
Communication

Caged glucosamine-6-phosphate for the light-control of riboswitch activity

B. Wulffen, M. C. R. Buff, M. Pofahl, G. Mayer and A. Heckel, Photochem. Photobiol. Sci., 2012, 11, 489
DOI: 10.1039/C1PP05242J

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