Jump to main content
Jump to site search

Issue 8, 2002
Previous Article Next Article

Structure of radicals derived from hydroxypyrimidines in aqueous solution

Author affiliations

Abstract

EPR spectra of radicals derived from the three isomeric trihydroxypyrimidines and from 2-hydroxypyrimidine were obtained either in reduction or oxidation conditions at various pH values. Additionally, three other pyrimidine derivatives, 2-thiobarbituric acid, 2-amino-4,6-dihydroxypyrimidine and 2-methyl-4,5,6-trihydroxypyrimidine, were studied in the same conditions. Reduced radicals were produced by reaction of the pyrimidines with the hydrated electron, the hydrogen atom and with the CO2˙ radical. In these conditions, the electron adducts as well as CO2˙ adducts were identified in most cases. Oxidized radicals were obtained by reaction of the substrates with OH˙, O˙, SO4˙, and Br2˙ radicals. The radicals detected and studied were either of the OH-adduct type or radicals derived from its dehydration. The radicals were investigated by using in situ radiolysis and photolysis EPR techniques.

Graphical abstract: Structure of radicals derived from hydroxypyrimidines in aqueous solution

Back to tab navigation

Article information


Submitted
01 May 2002
Accepted
24 May 2002
First published
20 Jun 2002

J. Chem. Soc., Perkin Trans. 2, 2002, 1412-1417
Article type
Paper

Structure of radicals derived from hydroxypyrimidines in aqueous solution

H. M. Novais, J. P. Telo and S. Steenken, J. Chem. Soc., Perkin Trans. 2, 2002, 1412
DOI: 10.1039/B204250A

Search articles by author

Spotlight

Advertisements