Issue 6, 2002
From the journal:

Journal of the Chemical Society, Perkin Transactions 2

Functionalization of C60 with diphosphonate groups: a route to bone-vectored fullerenes

Andrey L. Mirakyana  and  Lon J. Wilson*a  

* Corresponding authors

a Center for Nanoscale Science and Technology and Department of Chemistry, Rice University, PO Box 1892, MS-60, 77251-1892, Houston, Texas, USA
E-mail: durango@rice.edu
Fax: (713)3485155
Tel: (713)3483268

Abstract

A facile synthesis for derivatizing fullerenes with diphosphonate groups based on the Bingel reaction has been explored. Five different bisadduct isomers of C60 with tetraethyl methylenediphosphonate, CH2(PO3Et2)2, have been synthesized, separated and characterized by MALDI-TOF mass spectrometry and 31P{1H} and 13C NMR spectroscopy. Hydrolysis of the C60[C(PO3Et2)2]2 isomers generates water-soluble diphosphonic acids, C60[C(PO3H2)2]2 for future in vitro and in vivo studies in which mineralized bone tissue will be selectively targeted.

Graphical abstract: Functionalization of C60 with diphosphonate groups: a route to bone-vectored fullerenes

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Article information

DOI
https://doi.org/10.1039/B200145D
Article type
Paper
Submitted
08 Jan 2002
Accepted
04 Apr 2002
First published
23 Apr 2002

J. Chem. Soc., Perkin Trans. 2, 2002, 1173-1176

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Functionalization of C60 with diphosphonate groups: a route to bone-vectored fullerenes

A. L. Mirakyan and L. J. Wilson, J. Chem. Soc., Perkin Trans. 2, 2002, 1173 DOI: 10.1039/B200145D

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