Functionalized β-cyclodextrins: thermodynamic studies and NMR titration of 6-diethylenetriamine derivative
Abstract
A thermodynamic and spectroscopic investigation has been carried out on the protonation and copper(II) complexation of the 6-diethylenetriamine derivative of β cyclodextrins. By 13C NMR titration, the order of protonation of the three nitrogen atoms has been ascertained. The unusual entropy changes accompanying the different steps of protonation, as well as the copper(II) complexation, are discussed.