Issue 11, 1984

Effect of chlorine substitution on the structure and activity of 4-phenylthiosemicarbazide: crystal and molecular structure of 4-(4-chlorophenyl)thiosemicarbazide

Abstract

The crystal structure of 4-(4-chlorophenyl)thiosemicarbazide has been determined by direct methods. This p-chloro-substituted 4-phenylthiosemicarbazide, with greater antibacterial activity than its unsubstituted precursor, crystallises in the space group P21/c with a= 14.594(4), b= 10.495(5), c= 12.384(4)Å, β= 104.73(2)°, Z= 8, Dc= 1.469 g cm–3, and µ(Mo-Kα)= 5.83 cm–1. The structure has been refined using 1 967 reflections with I[gt-or-equal] 3σ(I). The antibacterial activity of both the present compound and its precursor has been attributed to electron delocalisatoin in the thiosemicarbazide moiety enhancing both its donor and reductive capacities.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 2, 1984, 1729-1733

Effect of chlorine substitution on the structure and activity of 4-phenylthiosemicarbazide: crystal and molecular structure of 4-(4-chlorophenyl)thiosemicarbazide

A. K. Nandi, S. Chaudhuri, S. K. Mazumdar and S. Ghosh, J. Chem. Soc., Perkin Trans. 2, 1984, 1729 DOI: 10.1039/P29840001729

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