Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 16, 2002
Previous Article Next Article

A new synthesis of temozolomide

Author affiliations

Abstract

An efficient condensation reaction between nitrosoimidazoles and phenyl methylcarbazate forms the basis of a new synthetic route to phenyloxycarbonyl substituted triazenylimidazoles. Exposure of these triazenes to diffuse daylight is sufficient to induce (E) to (Z)-isomerization of the triazene –N[double bond, length as m-dash]N– bond, resulting in spontaneous formation of temozolomide in high yield.

Graphical abstract: A new synthesis of temozolomide

Back to tab navigation

Article information


Submitted
11 Jun 2002
Accepted
20 Jun 2002
First published
11 Jul 2002

J. Chem. Soc., Perkin Trans. 1, 2002, 1877-1880
Article type
Paper

A new synthesis of temozolomide

M. J. Wanner and G. Koomen, J. Chem. Soc., Perkin Trans. 1, 2002, 1877
DOI: 10.1039/B205614C

Search articles by author

Spotlight

Advertisements