Issue 5, 2001

Microchip-based synthesis and total analysis systems (µSYNTAS): chemical microprocessing for generation and analysis of compound libraries

Abstract

A miniaturised-SYNthesis and Total Analysis System (µSYNTAS) integrating a silicon-machined chemical microprocessor and time-of-flight mass spectrometry (TOF-MS) is used for the generation of compound libraries based on sub-reactions of an Ugi multicomponent reaction (MCR). The microreactor—based on the concept of an AND logic operator—allowed the coupling of serially-switched solution-phase library generation with on-line compound analysis and identification. In addition, the µSYNTAS allowed real-time parallel-processing of MCR sub-reactions; in contrast to combinatorial techniques employing a solid support for reagent and product isolation, the µSYNTAS protocol required no additional preparation or work-up procedures.

Graphical abstract: Microchip-based synthesis and total analysis systems (µSYNTAS): chemical microprocessing for generation and analysis of compound libraries

Article information

Article type
Paper
Submitted
09 Nov 2000
Accepted
12 Jan 2001
First published
09 Feb 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 514-518

Microchip-based synthesis and total analysis systems (µSYNTAS): chemical microprocessing for generation and analysis of compound libraries

M. C. Mitchell, V. Spikmans, A. Manz and A. J. de Mello, J. Chem. Soc., Perkin Trans. 1, 2001, 514 DOI: 10.1039/B009037I

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements