Issue 2, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

A conjugate addition–radical cyclisation approach to sesquiterpene-phenol natural products

Barry S. Crombie,a   Colin Smith,b   Christalla Z. Varnavasa  and  Timothy W. Wallace*a  

* Corresponding authors

a Department of Chemistry and Applied Chemistry, University of Salford, Salford, UK
E-mail: T.W.Wallace@salford.ac.uk

b Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, UK

Abstract

The polycyclic ring system which forms the nucleus of a series of sesquiterpene-phenol natural products, including the antimalarial 15-oxopuupehenol, can be constructed in racemic form in four efficient steps, the last of these being a stereoselective manganese(III) acetate-mediated radical cyclisation reaction.

Graphical abstract: A conjugate addition–radical cyclisation approach to sesquiterpene-phenol natural products

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Article information

DOI
https://doi.org/10.1039/B005617K
Article type
Paper
Submitted
12 Jul 2000
Accepted
04 Sep 2000
First published
02 Jan 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 206-215

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A conjugate addition–radical cyclisation approach to sesquiterpene-phenol natural products

B. S. Crombie, C. Smith, C. Z. Varnavas and T. W. Wallace, J. Chem. Soc., Perkin Trans. 1, 2001, 206 DOI: 10.1039/B005617K

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