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Issue 24, 2000
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(Fluoren-9-ylmethoxy)carbonyl (Fmoc) amino acid azides: Synthesis, isolation, characterisation, stability and application to synthesis of peptides

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Abstract

The synthesis of Fmoc amino acid azides starting from the corresponding protected amino acid and sodium azide (NaN3) by the mixed anhydride method using isobutoxycarbonyl chloride (IBC-Cl) or by the acid chloride method is described. Isolated as crystalline solids, they are stable at room temperature, with a long shelf-life, as well as in aqueous washing operations. They are useful as coupling agents in peptide synthesis.

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Publication details

The article was received on 17 Aug 2000, accepted on 19 Oct 2000 and first published on 05 Dec 2000


Article type: Paper
DOI: 10.1039/B006756N
Citation: J. Chem. Soc., Perkin Trans. 1, 2000,0, 4328-4331

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    (Fluoren-9-ylmethoxy)carbonyl (Fmoc) amino acid azides: Synthesis, isolation, characterisation, stability and application to synthesis of peptides

    V. V. S. Babu, K. Ananda and G. Vasanthakumar, J. Chem. Soc., Perkin Trans. 1, 2000, 0, 4328
    DOI: 10.1039/B006756N

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