Issue 11, 2000

Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives

Abstract

New methodology for the synthesis of non-racemic isoindolinone targets has been developed through application of tricyclic γ-lactam substrates as N-acyliminium ion precursors in reactions with carbon and hydride nucleophiles. Removal of the phenylglycinol derived chiral auxiliary can be achieved without loss of stereochemical integrity at the newly created asymmetric centre, and we report a novel method for this key step using conc. sulfuric acid.

Additions and corrections

Article information

Article type
Paper
Submitted
25 Feb 2000
Accepted
18 Apr 2000
First published
16 May 2000

J. Chem. Soc., Perkin Trans. 1, 2000, 1715-1721

Approaches to the synthesis of non-racemic 3-substituted isoindolinone derivatives

S. M. Allin, C. J. Northfield, M. I. Page and A. M. Z. Slawin, J. Chem. Soc., Perkin Trans. 1, 2000, 1715 DOI: 10.1039/B001569P

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements