SCHEDULED MAINTENANCE
A concise, multigram synthesis of (4R)-2-[(1′R,2′S
)-1′,2′-methano-3′-(tert-butyldiphenylsiloxy)propyl]-4-hydroxymethyl-4,5-dihydrothiazole has been achieved, and this compound has been used for the production of a range of analogues of the anti-mitotic agent curacin A.
B. K. D. Martin, J. Mann and O. A. Sageot, J. Chem. Soc., Perkin Trans. 1, 1999, 2455 DOI: 10.1039/A904378K
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