Condensation of 5-aminothieno[2,3-c]pyridazine-6-carbaldehyde with aliphatic primary amines. Synthesis of new heterocyclic 2,6,9-triazabicyclo[3.3.1]nonane derivatives

Abstract

5-Amino-3,4-diphenylthieno[2,3-c]pyridazine-6-carbaldehyde (2) undergoes condensation with aliphatic primary amines to give the corresponding 2,6,9-triazabicyclo[3.3.1]nonane derivatives 1 with different substituents at position 14. The molecular and crystal structure of 1b (R = Bu) have been determined by X-ray analysis. A suitable mechanism for the formation of 1 is proposed.