Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 17, 1998
Previous Article Next Article

First asymmetric synthesis of the Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S )-2-[2′-(N-hydroxycarbamoylmethyl)-3′-phenylpropionylamino]cyclohexane-1-carboxylic acid

Abstract

The first asymmetric synthesis of Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S )-2-[2′-(N-hydroxycarbamoylmethyl)-3′-phenylpropionylamino]cyclohexane-1-carboxylic acid is achieved using lithium amide (R)-5 and pyrrolidinone auxiliary (R)-6; the pyrrolidinone auxiliary is used to create (2S )-benzylsuccinic acid derivative (S )-4 while lithium amide (R)-5 is used to synthesize tert-butyl (1S,2R)-2-aminocyclohexanecarboxylate 3.

Back to tab navigation

Article information


J. Chem. Soc., Perkin Trans. 1, 1998, 2629-2634
Article type
Paper

First asymmetric synthesis of the Kelatorphan-like enkephalinase inhibitor (1S,2R,2′S )-2-[2′-(N-hydroxycarbamoylmethyl)-3′-phenylpropionylamino]cyclohexane-1-carboxylic acid

S. G. Davies and D. J. Dixon, J. Chem. Soc., Perkin Trans. 1, 1998, 2629
DOI: 10.1039/A804660C

Search articles by author

Spotlight

Advertisements