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Issue 17, 1997
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Synthesis of a cis-conformationally restricted peptide bond isostere and its application to the inhibition of the HIV-1 protease

Abstract

A synthesis of a new, tetrazole-based, cis-constrained hydroxyethylamine peptide bond isostere is reported. This has been used to produce a new class of HIV-1 protease inhibitor.

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Article information


J. Chem. Soc., Perkin Trans. 1, 1997, 2475-2482
Article type
Paper

Synthesis of a cis-conformationally restricted peptide bond isostere and its application to the inhibition of the HIV-1 protease

A. D. Abell and G. J. Foulds, J. Chem. Soc., Perkin Trans. 1, 1997, 2475
DOI: 10.1039/A702458D

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