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Issue 13, 1997
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Three component aminoalkylation of aldehydes by functionalizedorganozinc compounds promoted by lithium perchlorate (LiClO4)

Abstract

The one-pot synthesis of several N,N-dialkylamino esters is reported. Treatment of aldehydes 1 (aliphatic and aromatic) with (trimethylsilyl)dialkylamines 2, in the presence of LiClO4 in diethyl ether presumably gives the intermediates 3. Reaction of these intermediates 3 with functionalized organozinc reagents, RZnBr, produces a variety of N,N-dialkylamino esters in a short time (about 1 h) and in good to moderate yields. The pure products are isolated by extraction with cold hydrochloric acid.

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Article type: Paper
DOI: 10.1039/A700371D
J. Chem. Soc., Perkin Trans. 1, 1997, 1983-1986

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    Three component aminoalkylation of aldehydes by functionalized organozinc compounds promoted by lithium perchlorate (LiClO4)

    M. R. Saidi, H. R. Khalaji and J. Ipaktschi, J. Chem. Soc., Perkin Trans. 1, 1997, 1983
    DOI: 10.1039/A700371D

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