The synthesis of variously substituted 8,9,10,11-tetraoxatricyclo[5.2.1.12.6]undecan-4-ones by ozonolysis of various 8-oxabicyclo[3.2.1]oct-6-en-3-ones is described. Several of these stable ozonides exhibited activity (IC50s of 2–20 microgram cm–3) against a chloroquine-resistant strain of the malaria parasite Plasmodium falciparum.
L. de Almeida Barbosa, D. Cutler, J. Mann, M. J. Crabbe, G. C. Kirby and D. C. Warhurst, J. Chem. Soc., Perkin Trans. 1, 1996, 1101 DOI: 10.1039/P19960001101
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