Issue 10, 1995

Synthesis of N-aminomethylpyrrolidin-2-ones

Abstract

Pyrrolidin-2-ones react with formaldehyde and chlorotrimethylsilane to give 1-chloromethylpyrrolidin-2-ones which upon subsequent reaction with primary and secondary amines give 1-aminomethylpyrrolidin-2-ones in good yield.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 1317-1322

Synthesis of N-aminomethylpyrrolidin-2-ones

P. Chen, D. Suh and M. B. Smith, J. Chem. Soc., Perkin Trans. 1, 1995, 1317 DOI: 10.1039/P19950001317

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