A chemoenzymatic synthesis of enantiomerically pure (R)- and (S)-2-methyldecan-1-ol
Abstract
(R)- and (S)-2-methyldecan-1-ol 3a has been prepared in >98% enantiomeric excess (ee) by transesterification with vinyl acetate in chloroform in the presence of Pseudomonas fluorescens lipase. Oxidation of the alcohol 3a affords nearly optically pure 2-methyldecanoic acid 3b