A concise synthesis of the pseudoguaianolide skeleton
Abstract
We describe the conversion of 1,3-dimethyl-8-oxabicyclo[5.3.0]dec-3-ene-2,9-dione into 1,3-dimethyl-6-oxatricyclo[8.3.0.03,7]tridec-11-ene-2,5,13-trione (pseudoguaianolide skeleton) in eight steps. This completes a ten-stage synthesis of this system from the readily available 2,4-dimethyl-8-oxabicyclo[3.2.1]octan-3-one.