Issue 3, 1992

Pig liver alcohol dehydrogenase catalysed stereoselective reduction of cage-shaped ketones. Preparation of axially chiral (–)-(R)-adamantane-2,6-diol with high enantiomeric purity

Abstract

In a study of the stereoselective reductions of various cage-shaped ketones catalysed by pig liver alcohol dehydrogenase (PLADH), a typical axially chiral diol, (–)-(R)-adamantane-2,6-diol 12a with high enantiomeric purity was prepared by asymmetric reduction of keto ester 11d; based on this a new, remarkable function of the active site of the enzyme, which serves to enhance the stereoselectivity of the reaction is suggested.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1992, 317-319

Pig liver alcohol dehydrogenase catalysed stereoselective reduction of cage-shaped ketones. Preparation of axially chiral (–)-(R)-adamantane-2,6-diol with high enantiomeric purity

Y. Hirose, M. Okutsu, M. Anzai, K. Naemura and H. Chikamatsu, J. Chem. Soc., Perkin Trans. 1, 1992, 317 DOI: 10.1039/P19920000317

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