Tandem cycloaddition–enzymatic transesterification. An enantioselective Diels–Alder reaction equivalent

Abstract

Tandem cycloaddition–enzymatic transesterification with pancreatic pig upase or the lipase from Candida ciclindracea carried out in ethyl, vinyl, or isopropenyl acetate gives rise to optically active Diels–Alder type derivatives from symmetrical precursors with both high enantioselectivity and chemical yield.