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Issue 6, 1988
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Studies in terpenoid biosynthesis. Part 35. Biosynthetic sequences leading to the diterpenoid aphidicolin in Cephalosporium aphidicola

Abstract

[17-14C]-Labelled samples of 18-hydroxyaphidicol-16-ene,3α, 18-dihydroxyaphidicol-l6-ene, 16β,17 and 16β,18-dihydroxyaphidicolane, and 3α, 16β, 18- and 16β,17,18-trihydroxyaphidicolane have been prepared from aphidicolin and shown to be incorporated into aphidicolin by Cephalosporium aphidicola to the extent of 0.86, 16.4, 3.5, 20.5, 52.6, and 16.9%, respectively. These results suggest that although the major pathway of aphidicolin biosynthesis involves the 16β-alcohols, the 16-enes may also be utilized whilst a metabolic grid relationship may exist between the variously hydroxylated 16β-alcohols.

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Article information


J. Chem. Soc., Perkin Trans. 1, 1988, 1477-1480
Article type
Paper

Studies in terpenoid biosynthesis. Part 35. Biosynthetic sequences leading to the diterpenoid aphidicolin in Cephalosporium aphidicola

M. J. Ackland, J. F. Gordon, J. R. Hanson, B. L. Yeoh and A. H. Ratcliffe, J. Chem. Soc., Perkin Trans. 1, 1988, 1477
DOI: 10.1039/P19880001477

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