SCHEDULED MAINTENANCE
Structural isomers (15) of monothiathromboxane A2 have been prepared from the half-ester (1). The basic strategy involved introduction of the ‘bottom’ side-chain by Michael addition, lactonisation, removal of ethoxycarbonyl, and conventional introduction of the ‘top’ side-chain. A link with a published dithiathromboxane synthesis is described.
B. P. McDonald, R. W. Steele, J. K. Sutherland, B. W. Leslie and A. Brewster, J. Chem. Soc., Perkin Trans. 1, 1988, 675 DOI: 10.1039/P19880000675
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