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Issue 0, 1987
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Synthesis of sequential polydepsipeptides involving depsipeptide formation by the 2-nitrophenylsulphenyl N-carboxy α-amino acid anhydride (Nps–NCA) method

Abstract

Sequential polydepsipeptides containing a tripeptide sequence Ala-Ala-Glu(OEt) and various α-hydroxy acids have been successfully prepared by polycondensation of tetradepsipeptide pentachlorophenyl esters. The latter were synthesized by preparation of didepsipeptide free acids by the Nps-NCA method followed by active esterification and peptide chain elongation by the so-called ‘back-up’ procedure.

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Article type: Paper
DOI: 10.1039/P19870002249
J. Chem. Soc., Perkin Trans. 1, 1987, 2249-2251

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    Synthesis of sequential polydepsipeptides involving depsipeptide formation by the 2-nitrophenylsulphenyl N-carboxy α-amino acid anhydride (Nps–NCA) method

    R. Katakai, J. Chem. Soc., Perkin Trans. 1, 1987, 2249
    DOI: 10.1039/P19870002249

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