Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 27th March 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 0, 1985
Previous Article Next Article

Synthetic studies on antibiotic validamycins. Part 11. Synthesis of validamycin A

Abstract

The antibiotic validamycin A (1a) has been synthesized for the first time (as its undeca-O-acetate) by glycosylation of the partially protected derivative (8) of the aglycone, validoxylamine A (2a), with 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl chloride (11), followed by deprotection, thereby establishing the structure previously assigned. The totally O-acetytated derivative (19) of 7-deoxyvalidemycin A has been synthesized in a similar fashion.

Back to tab navigation

Article type: Paper
DOI: 10.1039/P19850002369
Citation: J. Chem. Soc., Perkin Trans. 1, 1985,0, 2369-2374

  •   Request permissions

    Synthetic studies on antibiotic validamycins. Part 11. Synthesis of validamycin A

    S. Ogawa, T. Nose, T. Ogawa, T. Toyokuni, Y. Iwasawa and T. Suami, J. Chem. Soc., Perkin Trans. 1, 1985, 0, 2369
    DOI: 10.1039/P19850002369

Search articles by author

Spotlight

Advertisements