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Issue 0, 1985
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Chiral synthesis of polyketide-derived natural products. Part 3. Stereocontrolled synthesis of a chiral fragment corresponding to both the C-1—C-4 and C-9—C-12 units of erythromycin A from D-glucose

Abstract

A chiral synthon, 3,6-dideoxy-1,2-O-isopropylidene-3-C-methyl-β-L-lyxo-hexofuranos-5-ulose (7), for the total synthesis of erythromycin A (1) corresponding to both the C-1—C-4 and C-9—C-12 fragments was synthesiszed highly stereoselectively from D-glucose (2)via stereoselective hydrogenation of 3,6-dideoxy-1,2-O-isopropylidene-3-C-methyl-α-D-glycero-hex-3-enofuranos-5-ulose (12).

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Article information


J. Chem. Soc., Perkin Trans. 1, 1985, 1-5
Article type
Paper

Chiral synthesis of polyketide-derived natural products. Part 3. Stereocontrolled synthesis of a chiral fragment corresponding to both the C-1—C-4 and C-9—C-12 units of erythromycin A from D-glucose

Y. Oikawa, T. Nishi and O. Yonemitsu, J. Chem. Soc., Perkin Trans. 1, 1985, 1
DOI: 10.1039/P19850000001

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