Synthesis of C-nucleosides. Part 14. 5(3)-Glycosyl-1,2,4-triazole-3(5) carboxamides as analogues of ribavirin
Alkyl thioimidates react with hydrazides of methyl hydrogen oxalate and oxamic acid to yield methyl 1,2,4-triazole 3(5)-carboxylates and -carboxamides. Ribo-, deoxyribo- and arabino-C-nucleoside analogues of ribavirin have been prepared and their structures established by n.m.r. and mass spectrometry.