SCHEDULED MAINTENANCE
The normal five-step procedure for the process indicated in the title has been shortened to three steps by using the reaction between diazomethane and a cyclic anhydride to prepare the intermediate diazo-ketone ester. This is illustrated by the synthesis of methyl 2-(1-benzyl-5-methoxycarbonylpyrrolidin-2-yl)acetate from 1-benzylpyrrolidine-2,5-dicarboxylic anhydride.
E. W. Della and M. Kendall, J. Chem. Soc., Perkin Trans. 1, 1973, 2729 DOI: 10.1039/P19730002729
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