6,7-Unsaturated 5β-steroids as intermediates for labelling with isotopic hydrogen
Abstract
5β-Pregn-6-ene-3α,20α-diol (I)(Δ6-pregnanediol) and 3α-hydroxy-5β-androst-6-en-17-one (II)(Δ6-aetiocholanolone) have been prepared and reduced to give their parent saturated compounds. Deuteriation experiments with model Δ6-5β-cholestanes show that catalytic hydrogenation is not stereospecific.