Sequential polypeptides. Part VI. The synthesis of some sequential polypeptide collagen models containing proline analogues

Abstract

Syntheses of poly-(L-alanylglycyl-L-thiazolidine-4-carboxylic acid) and of poly-(L-piperidine-2-carbonyl-L-alanylglycine)via the corresponding tripeptide pentachlorophenyl esters and of poly-(glycyl-L-piperidine-2-carbonyl-L-alanine) and poly-(glycyl-L-azetidine-2-carbonyl-L-alanine)via the corresponding tripeptide 2-hydroxy-phenyl esters are described. All of the polydisperse preparations were of low apparent molecular weight except the polymer containing thiazolidine-4-carboxylic acid, which on viscosity criteria had a weight average molecular weight in the region of 10.000.