Polypeptides. Part XIX. The synthesis of some sequential polypeptides of β-methyl aspartate and γ-methyl glutamate

Abstract

Four sequential polypeptides containing β-methyl aspartyl and γ-methyl glutamyl residues have been prepared by polymerisation of the corresponding oligopeptide N-succinimidyl esters, which were synthesised by conventional methods, using the benzyloxycarbonyl group for N-protection and the t-butyl ester group for carboxy-protection. The polypeptides had molecular weights (M_n) of about 10,000, and very little racemisation (ca. 2%) accompanied the polymerisations.