Bifunctional squaramide catalyzed asymmetric synthesis of chiral α-mercaptosilanes†
Abstract
Bifunctional squaramide-catalyzed nucleophilic addition of thiophenols to easily available β-silyl α,β-unsaturated carbonyl compounds has been successfully developed. A structurally diverse set of chiral α-mercaptosilanes was efficiently prepared in good to excellent yields with acceptable enantioselectivities. The reaction features mild reaction conditions, a broad substrate scope, and easy scale-up.
- This article is part of the themed collection: Catalysis & biocatalysis in OBC