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Issue 9, 2021
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Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus Amphichorda guana

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Abstract

Two potential non-ribosomal peptide synthetases (NRPSs) were identified in the genome of a guanophilic fungus Amphichorda guana by bioinformatics analysis and gene knockout experiments. Liquid chromatography coupled with mass spectrometry (LC-MS) guided isolation led to the discovery of a new cyclodepsipeptide isaridin H (1) and seven known analogs, desmethylisaridin E (2), isaridin E (3), isariin A (4), iso-isariin B (5), iso-isariin D (6), isariin E (7), and nodupetide (8). The absolute configuration of isaridin H (1) was achieved by Marfey's method. Isaridin H (1) showed significant antifungal activity against Botrytis cinerea and Alternaria solani.

Graphical abstract: Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus Amphichorda guana

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Supplementary files

Article information


Submitted
20 Jan 2021
Accepted
12 Feb 2021
First published
12 Feb 2021

Org. Biomol. Chem., 2021,19, 1960-1964
Article type
Communication

Genomics-driven discovery of a new cyclodepsipeptide from the guanophilic fungus Amphichorda guana

M. Liang, H. Lyu, Z. Ma, E. Li, L. Cai and W. Yin, Org. Biomol. Chem., 2021, 19, 1960 DOI: 10.1039/D1OB00100K

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