Issue 40, 2020
From the journal:

Organic & Biomolecular Chemistry

A directing group free Pd(ii)-catalysed desulfitative C6-arylation of 2-pyridone using an arylsulfonyl chloride†

Ujjwal Karmakara  and  Rajarshi Samanta ORCID logo *a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India
E-mail: rsamanta@chem.iitkgp.ac.in

Abstract

A Pd(II)-catalysed direct desulfitative arylation was realized at the C6-position of the 2-pyridone scaffold. Aryl sulfonyl chloride was used as an alternative arylating agent. The required site-selectivity occurred without the strategic installation of a heteroatom containing directing group. Preliminary mechanistic studies revealed that radical species were involved during this process.

Graphical abstract: A directing group free Pd(ii)-catalysed desulfitative C6-arylation of 2-pyridone using an arylsulfonyl chloride

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Article information

DOI
https://doi.org/10.1039/D0OB01716G
Article type
Communication
Submitted
19 Aug 2020
Accepted
24 Sep 2020
First published
24 Sep 2020

Org. Biomol. Chem., 2020,18, 8079-8083

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A directing group free Pd(II)-catalysed desulfitative C6-arylation of 2-pyridone using an arylsulfonyl chloride

U. Karmakar and R. Samanta, Org. Biomol. Chem., 2020, 18, 8079 DOI: 10.1039/D0OB01716G

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