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Issue 41, 2020
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Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

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Abstract

The Henry reaction was performed using microwave heating within the deep eutectic solvent (DES) choline chloride/urea (ChCl/urea) which acted as both the catalyst and solvent for the reaction. The optimisation of the conditions (temperature, heating mode, time, DES) allowed 1,3-dinitropropane derivatives to be obtained via tandem Henry reaction/Michael addition, in one step from a range of different aromatic aldehydes in high yields and under mild reaction conditions.

Graphical abstract: Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

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Supplementary files

Article information


Submitted
23 Jul 2020
Accepted
20 Aug 2020
First published
20 Aug 2020

Org. Biomol. Chem., 2020,18, 8395-8401
Article type
Paper

Deep eutectic solvent as solvent and catalyst: one-pot synthesis of 1,3-dinitropropanes via tandem Henry reaction/Michael addition

G. Colombo Dugoni, A. Sacchetti and A. Mele, Org. Biomol. Chem., 2020, 18, 8395
DOI: 10.1039/D0OB01516D

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