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Issue 28, 2020
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An efficient approach for the synthesis of new (±)-coixspirolactams

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Coixspirolactams, spiro[oxindole-γ-lactones], are found in adlay seeds and exhibit anticancer activity. A novel synthetic methodology was developed to enable an easy access to (±)-coixspirolactam A and a large number of new coixspirolactams in excellent overall yields. The exquisite exploitation of formamide reactivity was essential for the construction of oxindole and lactone scaffolds.

Graphical abstract: An efficient approach for the synthesis of new (±)-coixspirolactams

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Article information

28 May 2020
30 Jun 2020
First published
01 Jul 2020

Org. Biomol. Chem., 2020,18, 5458-5465
Article type

An efficient approach for the synthesis of new (±)-coixspirolactams

V. R. Nascimento, M. L. S. Suenaga and L. H. Andrade, Org. Biomol. Chem., 2020, 18, 5458
DOI: 10.1039/D0OB01104E

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