Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 28, 2020
Previous Article Next Article

An efficient approach for the synthesis of new (±)-coixspirolactams

Author affiliations

Abstract

Coixspirolactams, spiro[oxindole-γ-lactones], are found in adlay seeds and exhibit anticancer activity. A novel synthetic methodology was developed to enable an easy access to (±)-coixspirolactam A and a large number of new coixspirolactams in excellent overall yields. The exquisite exploitation of formamide reactivity was essential for the construction of oxindole and lactone scaffolds.

Graphical abstract: An efficient approach for the synthesis of new (±)-coixspirolactams

Back to tab navigation

Supplementary files

Article information


Submitted
28 May 2020
Accepted
30 Jun 2020
First published
01 Jul 2020

Org. Biomol. Chem., 2020,18, 5458-5465
Article type
Paper

An efficient approach for the synthesis of new (±)-coixspirolactams

V. R. Nascimento, M. L. S. Suenaga and L. H. Andrade, Org. Biomol. Chem., 2020, 18, 5458
DOI: 10.1039/D0OB01104E

Social activity

Search articles by author

Spotlight

Advertisements