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Issue 28, 2020
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Photoactive NO hybrids with pseudo-zero-order release kinetics for antimicrobial applications

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Abstract

Bacterial infection is a major threat to the health and life of humans due to the development of drug resistance, which is related to biofilm formation. Nitric oxide (NO) has emerged as an important factor in regulating biofilm formation. In order to harness the potential benefits of NO and develop effective antibacterial agents, we designed and synthesized a new class of NO hybrids in which the active scaffold benzothienoazepine was tagged with a nitroso group and further conjugated with quaternary ammoniums or phosphoniums. The temporal release of NO from these hybrids can be achieved by photoactivation. Interestingly, the NO release follows a pseudo-zero-order kinetics, which is easily determined by measuring the fluorescent benzothienoazepine or NO. Compared to the positive control ciprofloxacin, the NO hybrid with triphenyl phosphonium (TPP) exhibited more effective activity against S. aureus biofilm in darkness. Irradiation of the NO hybrid led to higher inhibition against S. aureus biofilm compared to the parental NO hybrid in darkness or the corresponding NO-released product, indicating the combined effect of NO and the NO-released product. Therefore, this new class of NO hybrids includes very promising antimicrobial agents and this work provides a new way for the design of highly effective antimicrobial agents.

Graphical abstract: Photoactive NO hybrids with pseudo-zero-order release kinetics for antimicrobial applications

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Supplementary files

Article information


Submitted
17 Mar 2020
Accepted
01 Jul 2020
First published
01 Jul 2020

Org. Biomol. Chem., 2020,18, 5473-5480
Article type
Paper

Photoactive NO hybrids with pseudo-zero-order release kinetics for antimicrobial applications

Y. Liao, Z. Ye, M. Qian, X. Wang, Y. Guo, G. Han, Y. Song, J. Hou and Y. Liu, Org. Biomol. Chem., 2020, 18, 5473
DOI: 10.1039/D0OB00564A

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