Issue 31, 2020
From the journal:

Organic & Biomolecular Chemistry

The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source†

Bifu Liu,a   Min Liu, ORCID logo *ab   Qiang Li, ORCID logo cd   Yuanhua Li,a   Kejun Fenga  and  Yongbo Zhou ORCID logo d  

* Corresponding authors

a School of Chemistry and Materials Engineering, Huizhou University, Huizhou, Guangdong, China
E-mail: minliu1018@163.com

b Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, China

c College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng, Shandong 252059, China

d College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China

Abstract

The ligand-free palladium-catalyzed C3-cyanation of indoles via direct C–H functionalization was achieved. This protocol, utilizing CH3CN as a green and readily available cyanide source, produced the desired products in moderate to good yields through transition-metal-catalyzed C–CN bond cleavage.

Graphical abstract: The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source

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Article information

DOI
https://doi.org/10.1039/D0OB00485E
Article type
Paper
Submitted
06 Mar 2020
Accepted
20 Jul 2020
First published
22 Jul 2020

Org. Biomol. Chem., 2020,18, 6108-6114

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The palladium-catalyzed direct C3-cyanation of indoles using acetonitrile as the cyanide source

B. Liu, M. Liu, Q. Li, Y. Li, K. Feng and Y. Zhou, Org. Biomol. Chem., 2020, 18, 6108 DOI: 10.1039/D0OB00485E

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