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Issue 10, 2020
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Iron(iii) chloride-promoted cyclization of α,β-alkynic tosylhydrazones with diselenides: synthesis of 4-(arylselanyl)-1H-pyrazoles

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Abstract

A highly efficient iron(III) chloride-promoted cyclization between α,β-alkynic tosylhydrazones and diselenides to form a 4-(arylselanyl)-1H-pyrazole skeleton is studied. This reaction forms C–N and C–Se bonds in one step by utilizing inexpensive iron(III) chloride instead of expensive transition metal additives. This strategy features easily synthesized substrates, mild reaction conditions and high tolerance to functional groups.

Graphical abstract: Iron(iii) chloride-promoted cyclization of α,β-alkynic tosylhydrazones with diselenides: synthesis of 4-(arylselanyl)-1H-pyrazoles

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Article information


Submitted
09 Jan 2020
Accepted
05 Feb 2020
First published
18 Feb 2020

Org. Biomol. Chem., 2020,18, 1987-1993
Article type
Paper

Iron(III) chloride-promoted cyclization of α,β-alkynic tosylhydrazones with diselenides: synthesis of 4-(arylselanyl)-1H-pyrazoles

H. Yao, F. Li, J. Li, S. Wang and S. Ji, Org. Biomol. Chem., 2020, 18, 1987
DOI: 10.1039/D0OB00048E

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