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Issue 47, 2019
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Brønsted acid mediated intramolecular cyclopropane ring expansion/[4 + 2]-cycloaddition

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Abstract

A cascade reaction of 3-hydroxy-2-phenylisoindolin-1-one and cyclopropyl ketone has been developed via a BrØnsted acid-promoted ring-opening/intramolecular cross-cycloaddition/[4 + 2]-cycloaddition process. The developed methodology provides straightforward access to pentacyclic isoindolin-1-one derivatives under simple reaction conditions.

Graphical abstract: Brønsted acid mediated intramolecular cyclopropane ring expansion/[4 + 2]-cycloaddition

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Article information


Submitted
04 Nov 2019
Accepted
15 Nov 2019
First published
15 Nov 2019

Org. Biomol. Chem., 2019,17, 10004-10008
Article type
Communication

Brønsted acid mediated intramolecular cyclopropane ring expansion/[4 + 2]-cycloaddition

J. Li, S. Zhu, Q. Xu, L. Liu and S. Yan, Org. Biomol. Chem., 2019, 17, 10004
DOI: 10.1039/C9OB02379H

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