Issue 48, 2019
From the journal:

Organic & Biomolecular Chemistry

Ultrasound accelerated synthesis of O-alkylated hydroximides under solvent- and metal-free conditions†

Hongmei Jiang,ab   Xiaoyue Tang,c   Sihan Liu,a   Lian Wang,a   Haicheng Shen,a   Jiankui Yang,a   Huixian Wanga  and  Qing-Wen Gui ORCID logo *a  

* Corresponding authors

a College of Science, Hunan Agricultural University, Changsha 410128, People's Republic of China
E-mail: gqw1216@163.com, gqw1216@hunau.edu.cn

b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemical Engineering, Hunan University, Changsha 410082, People's Republic of China

c Department of Pharmaceutical Engineering, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People's Republic of China

Abstract

A novel, sustainable, environmentally friendly, high substrate scope, efficient, solvent-free and metal catalyst-free method for the cross-dehydrogenative coupling (CDC) reaction between N-hydroxyphthalimide (NHPI) and benzyl/ether compounds is described. This coupling reaction proceeds through ultrasound acceleration. Compared to conventional heating conditions, the use of ultrasound techniques not only improves the reaction efficiency and enhances the reaction rate but also minimizes the side reactions.

Graphical abstract: Ultrasound accelerated synthesis of O-alkylated hydroximides under solvent- and metal-free conditions

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Article information

DOI
https://doi.org/10.1039/C9OB02245G
Article type
Paper
Submitted
17 Oct 2019
Accepted
16 Nov 2019
First published
19 Nov 2019

Org. Biomol. Chem., 2019,17, 10223-10227

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Ultrasound accelerated synthesis of O-alkylated hydroximides under solvent- and metal-free conditions

H. Jiang, X. Tang, S. Liu, L. Wang, H. Shen, J. Yang, H. Wang and Q. Gui, Org. Biomol. Chem., 2019, 17, 10223 DOI: 10.1039/C9OB02245G

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