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Issue 47, 2019
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Theoretical calculation studies on the rearrangement mechanisms of arenesulfenanilides to generate o- and p-aminodiphenyl sulfides

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Abstract

The thermal and acid-catalyzed rearrangement mechanisms of arenesulfenanilides were investigated theoretically via density functional theory (DFT) calculations. The results indicate that the o-aminodiphenyl sulfide rearrangement involves a novel S[1,3]-sigmatropic shift followed by tautomerization, while the p-aminodiphenyl sulfide rearrangement proceeds via tandem [3,3]- and [3,3]-sigmatropic shifts followed by tautomerization under thermal conditions. Furthermore, computational studies reveal that water assists the proton shift more efficiently than anilines during tautomerization. Moreover, under the acid-catalyzed conditions, the o-aminodiphenyl sulfide rearrangement involves an S[1,3]-sigmatropic shift similar to that under the thermal conditions, while the p-aminodiphenyl sulfide rearrangement proceeds via cascade S[1,3]- and S[1,3]-sigmatropic shifts followed by water-aided tautomerization. The current theoretical studies provide new insights into the formation mechanism of o/p-aminodiphenyl sulfides in the arenesulfenanilide rearrangement and support the unprecedented suprafacial symmetry-allowed S[1,3]-sigmatropic shift with an inversion of the configuration in the migrating sulfur atom. The mechanism is affected by the reaction medium. Disproportionation of arenesulfenanilides into diaryl disulfides and azobenzenes is a competitive radical pathway during the arenesulfenanilide rearrangements.

Graphical abstract: Theoretical calculation studies on the rearrangement mechanisms of arenesulfenanilides to generate o- and p-aminodiphenyl sulfides

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Supplementary files

Article information


Submitted
11 Oct 2019
Accepted
15 Nov 2019
First published
15 Nov 2019

Org. Biomol. Chem., 2019,17, 10088-10096
Article type
Paper

Theoretical calculation studies on the rearrangement mechanisms of arenesulfenanilides to generate o- and p-aminodiphenyl sulfides

G. Liu, S. Hou and J. Xu, Org. Biomol. Chem., 2019, 17, 10088
DOI: 10.1039/C9OB02202C

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