The secondary structure of a heptapeptide containing trifluoromethyl-λ6-tetrafluorosulfanyl substituted amino acids

Akari Ikeda; Aimée Capellan; John T. Welch

doi:10.1039/C9OB01797F

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The secondary structure of a heptapeptide containing trifluoromethyl-λ⁶-tetrafluorosulfanyl substituted amino acids†

Akari Ikeda,^a Aimée Capellan^a and John T. Welch

*^a

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^a Department of Chemistry, University at Albany, SUNY, 1400 Washington Ave., Albany, NY 12222, USA
E-mail: jwelch@albany.edu

Abstract

Site specific introduction of the polar hydrophobic trifluoromethyl-λ⁶-tetrafluorosulfanyl (CF₃SF₄) group can effectively control the secondary structure of a heptapeptide, the minimum repeat unit of an α-helix. The structural influence of CF₃SF₄-containing amino acid on the heptapeptide was established using NMR methods.

This article is part of the themed collection: Chemical Biology in OBC

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Article information

DOI: https://doi.org/10.1039/C9OB01797F
Article type: Communication
Submitted: 14 Aug 2019
Accepted: 21 Aug 2019
First published: 21 Aug 2019

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Org. Biomol. Chem., 2019,17, 8079-8082

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The secondary structure of a heptapeptide containing trifluoromethyl-λ⁶-tetrafluorosulfanyl substituted amino acids

A. Ikeda, A. Capellan and J. T. Welch, Org. Biomol. Chem., 2019, 17, 8079 DOI: 10.1039/C9OB01797F

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Organic & Biomolecular Chemistry