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Issue 40, 2019
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Functionalization of activated methylene C–H bonds with nitroarenes and sulfur for the synthesis of thioamides

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Abstract

We report a method to obtain arylthioamides by the functionalization of sp3 C–H bonds in phenylacetic acids and benzyl alcohols. Reactions proceeded without the use of any solvents and were compatible with many functionalities and heterocycles. These conditions allow for a rapid synthesis of thioamides from simple, commercial substrates.

Graphical abstract: Functionalization of activated methylene C–H bonds with nitroarenes and sulfur for the synthesis of thioamides

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Article information


Submitted
08 Aug 2019
Accepted
27 Sep 2019
First published
04 Oct 2019

Org. Biomol. Chem., 2019,17, 8987-8991
Article type
Communication

Functionalization of activated methylene C–H bonds with nitroarenes and sulfur for the synthesis of thioamides

N. T. Do, K. M. Tran, H. T. Phan, T. A. To, T. T. Nguyen and N. T. S. Phan, Org. Biomol. Chem., 2019, 17, 8987
DOI: 10.1039/C9OB01751H

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