Jump to main content
Jump to site search

Issue 40, 2019
Previous Article Next Article

A convenient approach for the preparation of imidazo[1,2-a]-fused bicyclic frameworks via IBX/NIS promoted oxidative annulation

Author affiliations

Abstract

An IBX/NIS-induced intramolecular oxidative annulation of Mannich-type substrates is reported. This metal-free approach involving iodination, NH-oxidation, intramolecular C–N bond formation, and retro-Claisen–Schmidt sequence provides the construction of imidazo[1,2-a]pyridine, imidazo[1,2-a]pyrimidine as well as imidazo[1,2-a]pyrazine frameworks with yields up to 93%. In addition, a sequential one-pot process is also presented.

Graphical abstract: A convenient approach for the preparation of imidazo[1,2-a]-fused bicyclic frameworks via IBX/NIS promoted oxidative annulation

Back to tab navigation

Supplementary files

Article information


Submitted
02 Aug 2019
Accepted
21 Sep 2019
First published
27 Sep 2019

Org. Biomol. Chem., 2019,17, 9001-9007
Article type
Paper

A convenient approach for the preparation of imidazo[1,2-a]-fused bicyclic frameworks via IBX/NIS promoted oxidative annulation

Z. Makra, L. G. Puskás and I. Kanizsai, Org. Biomol. Chem., 2019, 17, 9001
DOI: 10.1039/C9OB01708A

Social activity

Search articles by author

Spotlight

Advertisements