Issue 43, 2019

Organocatalytic enantioselective conjugate addition of pyrazolin-5-ones to arylomethylidene malonates

Abstract

An efficient asymmetric organocatalytic conjugate addition reaction of pyrazolin-5-ones with arylomethylidene malonates has been successfully developed by employing bifunctional Cinchona derived thiourea organocatalysts. The protocol provides straightforward access to pyrazole substituted scaffolds in good yields with high stereocontrol.

Graphical abstract: Organocatalytic enantioselective conjugate addition of pyrazolin-5-ones to arylomethylidene malonates

Supplementary files

Article information

Article type
Paper
Submitted
01 Aug 2019
Accepted
11 Oct 2019
First published
11 Oct 2019

Org. Biomol. Chem., 2019,17, 9514-9523

Organocatalytic enantioselective conjugate addition of pyrazolin-5-ones to arylomethylidene malonates

A. Sharma, V. Sharma and S. S. Chimni, Org. Biomol. Chem., 2019, 17, 9514 DOI: 10.1039/C9OB01700C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements